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Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
Published on: May 25, 2018
Ewing's sarcoma of the kidney
Joel R Angel1, Anushayanthan Alfred, Ankit Sakhuja
1Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, USA. jangel@mcw.edu
International Journal of Clinical Oncology
|March 4, 2010
Summary
This study reports a rare case of renal primitive neuroectodermal tumor (PNET) in a young adult. The tumor exhibited unique genetic findings, including trisomy 7, highlighting a novel aspect of this aggressive cancer.
Area of Science:
- Oncology
- Pathology
- Genetics
Background:
- Primitive neuroectodermal tumors (PNETs) are rare, aggressive small round-cell tumors originating from neural crest cells.
- While typically found in the central nervous system (CNS), peripheral PNETs (pPNETs) are associated with the Ewing sarcoma family of tumors (EFTs).
- Renal PNETs are exceptionally uncommon, particularly in young adults, and are associated with a poor prognosis.
Observation:
- A young male presented with a rare renal PNET.
- Histopathological examination revealed pseudorosette formation, CD 99 positivity, and focal NSE positivity.
- Cytogenetic analysis identified the characteristic t(11;22)(q24;q12) translocation and the novel finding of trisomy 7.
Findings:
- This case represents the first documented instance of PNET with trisomy 7.
- The combination of specific histological features and genetic abnormalities provides a unique profile for this renal tumor.
- The presence of trisomy 7 may contribute to the aggressive nature of this renal PNET.
Implications:
- This case expands the understanding of the genetic landscape of peripheral PNETs.
- The identification of trisomy 7 in a renal PNET may offer new avenues for diagnostic and therapeutic strategies.
- Further research into the role of trisomy 7 in EFTs and other PNETs is warranted.
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