Related Experiment Video
Updated: Jun 15, 2026
Isolation and Culture of Rodent Microglia to Promote a Dynamic Ramified Morphology in Serum-free Medium
Published on: March 9, 2018
Current concepts of polymicrogyria
1Neuroradiology, University of California at San Francisco, San Francisco, CA 94143-0628, USA. Jim.Barkovich@radiology.ucsf.edu
Abstract:
Polymicrogyria is one of the most common malformations of cortical development. It has been known for many years and its clinical and MRI manifestations are well described. Recent advances in imaging, however, have revealed that polymicrogyria has many different appearances on MR imaging, suggesting that is may be a more heterogeneous malformation than previously suspected. The clinical and imaging heterogeneity of polymicrogyria is explored in this review.
Insights
Polymicrogyria, a common brain malformation, presents diverse appearances on MRI. This review explores the varied clinical and imaging features, indicating greater heterogeneity than previously understood.
Area of Science:
- Neuroscience
- Developmental Biology
- Radiology
Background:
- Polymicrogyria is a prevalent malformation of cortical development.
- Its clinical and magnetic resonance imaging (MRI) features are established.
- Recent imaging studies suggest increased heterogeneity.
Purpose of the Study:
- To review the diverse appearances of polymicrogyria on MRI.
- To explore the clinical heterogeneity associated with polymicrogyria.
- To discuss the implications of polymicrogyria's heterogeneity.
Main Methods:
- Review of recent literature on polymicrogyria.
- Analysis of imaging findings from various polymicrogyria cases.
- Correlation of imaging findings with clinical presentations.
Main Results:
- Polymicrogyria exhibits a wide spectrum of appearances on MRI.
- Significant variability exists in clinical manifestations.
- Imaging findings suggest a more heterogeneous condition than previously thought.
Conclusions:
- Polymicrogyria is a more heterogeneous malformation than recognized.
- Diverse MRI appearances reflect underlying heterogeneity.
- Further research is needed to understand the clinical and imaging spectrum.
