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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Neurocognitive function in schizophrenia with comorbid posttraumatic stress disorder.

Lisa A Duke¹, Daniel N Allen, Sylvia A Ross

¹Department of Psychology, University of Nevada Las Vegas, Las Vegas, NV 89154-5030, USA.

Journal of Clinical and Experimental Neuropsychology

|March 4, 2010

Summary

Individuals with schizophrenia and comorbid posttraumatic stress disorder (PTSD) show increased psychopathology but not substantially greater cognitive impairment compared to schizophrenia alone. This study explored the impact of co-occurring PTSD in schizophrenia patients.

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Area of Science:

Psychiatry
Neuroscience
Clinical Psychology

Background:

Schizophrenia (SZ) and posttraumatic stress disorder (PTSD) are associated with neurocognitive dysfunction.
Comorbidity of SZ and PTSD is common, yet their combined impact on cognition is understudied.

Purpose of the Study:

To investigate the neurocognitive and symptomatic effects of comorbid PTSD in individuals with schizophrenia.

Main Methods:

A study comparing four groups: healthy controls (C), PTSD only, SZ only, and SZ with comorbid PTSD (SZP).
Comprehensive diagnostic, symptom, and neurocognitive evaluations were administered.

Main Results:

The SZP group showed higher positive symptoms, general psychopathology, and PTSD symptoms, with fewer negative symptoms than the SZ group.
Both SZ groups performed worse than C and PTSD groups across all neurocognitive domains.
No significant difference in cognitive impairment was found between SZP and SZ groups.

Conclusions:

Comorbid PTSD in schizophrenia does not appear to substantially worsen cognitive impairment.
While symptom profiles differ, cognitive deficits are comparable between schizophrenia and schizophrenia with comorbid PTSD.