Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
Boundary Conditions for Current Density01:25

Boundary Conditions for Current Density

Current density becomes discontinuous across an interface of materials with different electrical conductivities. The normal component of the current density is continuous across the boundary.
Electrostatic Boundary Conditions01:16

Electrostatic Boundary Conditions

Consider an external electric field propagating through a homogeneous medium. When the electric field crosses the surface boundary of the medium, it undergoes a discontinuity. The electric field can be resolved into normal and tangential components. The amount by which the field changes at any boundary is given by the difference between the field components above and below the surface boundary.
The surface integral of an electric field is given by Gauss's law in integral form and is related to...
Magnetostatic Boundary Conditions01:28

Magnetostatic Boundary Conditions

An electric field suffers a discontinuity at a surface charge. Similarly, a magnetic field is discontinuous at a surface current. The perpendicular component of a magnetic field is continuous across the interface of two magnetic mediums. In contrast, its parallel component, perpendicular to the current, is discontinuous by the amount equal to the product of the vacuum permeability and the surface current. Like the scalar potential in electrostatics, the vector potential is also continuous...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ChatMDV: Reducing Technical Barriers in Bioinformatics Analysis using Large Language Models.

GigaScience·2026
Same author

Definition of Severity and Relapse for Vitiligo: An International Consensus Statement.

JAMA dermatology·2026
Same author

Service needs of people living with HIV in the UK (Positive Voices 2022): a cross-sectional survey.

The lancet. HIV·2026
Same author

Defining Important Aspects of Repigmentation in Vitiligo: Insights From Patients' Perspectives.

Pigment cell & melanoma research·2026
Same author

Iterative refinement of arbitrary micro-optical surfaces.

Optics express·2025
Same author

Delayed adrenaline administration prolongs adrenaline-to-ROSC interval in out-of-hospital cardiac arrest.

British paramedic journal·2025
Same journal

In Memory of Prof. Günter Allmaier (1956-2022).

Journal of mass spectrometry : JMS·2026
Same journal

A Step-by-Step Protocol From METASPACE to Biological Interpretation.

Journal of mass spectrometry : JMS·2026
Same journal

Rapid Determination of 13 Insecticides and Acaricides in Human Blood Using Dispersive Liquid-Liquid Microextraction Coupled With DART-MS/MS.

Journal of mass spectrometry : JMS·2026
Same journal

Sheath-Liquid CE-MS Interface: A Robust Infusion Platform for Native IMS-MS Analysis of Protein Assemblies and Their Conformers.

Journal of mass spectrometry : JMS·2026
Same journal

A Combined MS/MS and IMS Study Into the Fragmentation Pathway of Nifedipine.

Journal of mass spectrometry : JMS·2026
Same journal

Decoding Biothreats With FT-ICR-MS: Metabotyping of Bacillus cereus Spores Through Untargeted Metabolomics.

Journal of mass spectrometry : JMS·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Modelling mass analyzer performance with fields determined using the boundary element method.

J Raymond Gibson1, Kenneth G Evans, Stephen Taylor

  • 1The Department of Electrical Engineering and Electronics, The University of Liverpool, Brownlow Hill, Liverpool, L69 3GJ, UK. jrgjrg@liv.ac.uk

Journal of Mass Spectrometry : JMS
|March 4, 2010
PubMed
Summary
This summary is machine-generated.

The boundary element method (BEM) offers a more efficient and accurate approach for electric field calculations in mass analyzers compared to traditional finite element and finite difference methods. This computational advancement improves the modeling of quadrupole mass spectrometers and ion traps.

More Related Videos

Electric and Magnetic Field Devices for Stimulation of Biological Tissues
13:29

Electric and Magnetic Field Devices for Stimulation of Biological Tissues

Published on: May 15, 2021

Related Experiment Videos

Last Updated: Jun 15, 2026

Finite Element Modelling of a Cellular Electric Microenvironment
08:23

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Electric and Magnetic Field Devices for Stimulation of Biological Tissues
13:29

Electric and Magnetic Field Devices for Stimulation of Biological Tissues

Published on: May 15, 2021

Area of Science:

  • Computational Physics
  • Analytical Chemistry
  • Instrument Design

Background:

  • Computer modeling is crucial for designing mass analyzers, requiring accurate electric field data.
  • Existing methods like finite element (FE) and finite difference (FD) are computationally intensive.
  • Manufacturing imperfections significantly impact mass analyzer performance.

Purpose of the Study:

  • To evaluate the boundary element method (BEM) for electric field computation in mass analyzers.
  • To demonstrate BEM's efficiency and accuracy compared to FE and FD methods.
  • To improve the modeling of quadrupole mass spectrometers and ion traps.

Main Methods:

  • Electric field evaluation using the boundary element method (BEM).
  • Incorporation of modifications for enhanced accuracy in BEM calculations.
  • Application of simultaneous equation solution techniques to ensure physically realistic results.

Main Results:

  • BEM achieved comparable or higher accuracy than FE and FD methods with significantly reduced computation time and memory requirements.
  • Performance of linear quadrupole mass spectrometers (with various electrode geometries) was accurately predicted using BEM-computed fields.
  • The behavior of an ion trap mass spectrometer was successfully investigated using BEM.

Conclusions:

  • The boundary element method (BEM) provides a superior computational approach for electric field determination in mass analyzer design.
  • BEM enables more accurate prediction of mass spectrometer performance, accounting for design and manufacturing variations.
  • This method enhances the efficiency and reliability of computer modeling in mass spectrometry.