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Relationship between insulin resistance and inflamation markers in hemodialysis patients

Ali Borazan1, Dogan Nasir Binici

  • 1Mustafa Kemal University, Department of Nephrology, Hatay, Turkey. borazanali@hotmail.com

Renal Failure
|March 5, 2010
PubMed

Insights

Insulin resistance is linked to higher C-reactive protein and fibrinogen levels in hemodialysis patients. Assessing insulin resistance is crucial for determining cardiovascular disease risk in end-stage renal disease patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Syndrome

Background:

  • Cardiovascular disease (CVD) is a growing concern in end-stage renal disease (ESRD) patients.
  • Insulin resistance is a known risk factor for CVD.

Purpose of the Study:

  • To investigate the relationship between insulin resistance and inflammation markers in new hemodialysis (HD) patients.
  • To assess levels of C-reactive protein (CRP), fibrinogen, uric acid, and homocysteine in relation to insulin resistance.

Main Methods:

  • 64 insulin resistance-positive and 114 insulin resistance-negative patients undergoing hemodialysis were enrolled.
  • Fasting blood samples were analyzed for glucose, insulin, CRP, fibrinogen, uric acid, homocysteine, and lipid profiles.

Main Results:

  • Hemodialysis patients with insulin resistance showed significantly higher levels of fibrinogen and CRP compared to those without insulin resistance.
  • A significant positive correlation was observed between insulin resistance and serum CRP and fibrinogen levels (r = 0.258, p < 0.001).

Conclusions:

  • Elevated fibrinogen and CRP levels are associated with insulin resistance in hemodialysis patients.
  • Evaluating insulin resistance is essential for assessing coronary artery disease risk in HD patients.
Abstract

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