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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

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Related Experiment Video

Updated: Jun 15, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells
09:51

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Development of dendritic cell-based immunotherapy for autoimmunity.

Catharien M U Hilkens1, John D Isaacs, Angus W Thomson

  • 1Institute of Cellular Medicine, Musculoskeletal Research Group, Newcastle University, Newcastle upon Tyne, United Kingdom. catharien.hilkens@ncl.ac.uk

International Reviews of Immunology
|March 5, 2010
PubMed
Summary

Dendritic cells (DCs) are key immune cells that can be engineered into tolerogenic DCs. These modified DCs show promise for treating autoimmune diseases by restoring immune tolerance.

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Last Updated: Jun 15, 2026

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Area of Science:

  • Immunology
  • Cell Biology
  • Immunotherapy

Background:

  • Dendritic cells (DCs) are crucial antigen-presenting cells that regulate immune responses.
  • DCs play a vital role in maintaining immune tolerance to self-antigens by controlling auto-reactive T-cells.
  • Dysfunctional immune tolerance contributes to autoimmune diseases.

Purpose of the Study:

  • To explore the potential of dendritic cell-based immunotherapies for restoring immune tolerance in autoimmune diseases.
  • To highlight the therapeutic strategies involving modified tolerogenic dendritic cells (tDCs).

Main Methods:

  • Ex vivo modification of dendritic cells to induce stable tolerogenic function.
  • Utilizing modified DCs as cellular vaccines.
  • In vivo targeting of dendritic cells with antigen delivery systems.

Main Results:

  • Tolerogenic dendritic cells effectively induce antigen-specific T-cell tolerance.
  • Therapeutic effects of tDCs have been demonstrated in preclinical animal models of autoimmunity.

Conclusions:

  • Dendritic cell-based immunotherapy is a promising strategy for autoimmune disease treatment.
  • The primary challenge lies in translating tolerogenic dendritic cell therapy into clinical practice.