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Updated: Jun 15, 2026
A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats
Published on: August 15, 2025
Trauma does not aggravate deleterious effects of ischemia reperfusion injury on the lung
Makbule Ergin1, Ali Yeginsu, Huseyin Ozyurt
1Gaziosmanpasa University School of Medicine, Department of Thoracic Surgery, Ankara, Turkey.
Objectives:
Our purpose was to investigate the effects of ischemia-reperfusion injury on traumatized lungs.
Materials And Methods:
Twenty-four Wistar rats were used in the study. Rats were randomly divided into 4 groups. In the control group (group 1), only anesthesia and ventilation were used. In group 2, only lung ischemia-reperfusion injury was instituted. In group 3, only blunt chest trauma was instituted. And in group 4, lung ischemia reperfusion injury, consisting of 24 hours after the constitution of blunt chest trauma, was used. Lung damage and systemic inflammation parameters were evaluated.
Results:
All parameters (alveolar degeneration grades, alveolar macrophage and lymphocyte counts, antioxidant enzyme activities, cytokine levels, and bronchoalveolar lavage fluid albumin level) were higher in all groups than they were in the control group (P < .05). Only tissue malondialdehyde, tissue interleukin-8, and serum glutathione peroxidase levels were significantly higher in the lung ischemia-reperfusion group than they were in the trauma group (P < .05). The trauma + ischemia reperfusion group showed no significant difference when compared with the only ischemia-reperfusion or only trauma groups in any parameters (P > .05).
Conclusions:
The findings showed that lung trauma does not aggravate the deleterious effects of lung ischemia-reperfusion injury.
