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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Loose Connective Tissue01:26

Loose Connective Tissue

Loose connective tissue is found between many organs. Its main function is to absorb shock and bind tissues together. It also allows water, salts, and various nutrients to diffuse into cells that are embedded in it or present in adjacent tissues.
Adipose Tissue
Adipose tissue consists primarily of fat storage cells called adipocytes and little extracellular matrix. A large number of capillaries present within adipose tissue allow rapid mobilization of lipid molecules. White adipose tissue is...
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Related Experiment Video

Updated: Jun 15, 2026

Mechanical Micronization of Lipoaspirates for Regenerative Therapy
05:02

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Lipoatrophic connective tissue panniculitis.

Myriam Marque1, Bernard Guillot, Didier Bessis

  • 1Department of Dermatology, CHU Montpellier, Montpellier University 1, Montpellier, France. myriammarque@yahoo.fr

Pediatric Dermatology
|March 5, 2010
PubMed
Summary
This summary is machine-generated.

Connective tissue panniculitis is an autoimmune disorder affecting subcutaneous fat, presenting as inflammatory nodules and lipoatrophy. This uncommon condition has limited treatment options and can recur.

Related Experiment Videos

Last Updated: Jun 15, 2026

Mechanical Micronization of Lipoaspirates for Regenerative Therapy
05:02

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Area of Science:

  • Dermatology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Weber-Christian and Rothmann-Makai diseases are now recognized as specific panniculitis forms.
  • Connective tissue panniculitis (CTP) is an autoimmune subcutaneous fat disorder lacking other defined criteria.
  • CTP was first described by Winckelman et al. in 1980.

Observation:

  • A 4-year-old boy presented with annular subcutaneous inflammatory nodules.
  • The lesions resolved, resulting in lipoatrophy.
  • The condition recurred 8 years later.

Findings:

  • Histologic examination revealed granulomatous lipophagic panniculitis.
  • Previous reports highlight limited therapeutic options.
  • The condition exhibits chronic evolution and severe aesthetic sequelae.

Implications:

  • CTP is an uncommon condition with potential associations with other autoimmune disorders.
  • Early diagnosis and management are crucial for improving patient outcomes.
  • Further research is needed to explore novel therapeutic strategies for CTP.