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Chronic urticaria and celiac disease: a case report
Diego G Peroni1, Giulia Paiola, Laura Tenero
1Clinica Pediatrica Università di Verona, Verona, Italy. peroni.diego@tiscalinet.it
Pediatric Dermatology
|March 5, 2010
Summary
Chronic urticaria in children may indicate underlying celiac disease. This case highlights the importance of considering celiac disease in children with persistent hives, even without typical digestive symptoms.
Area of Science:
- Pediatric Gastroenterology
- Dermatology
- Immunology
Background:
- Celiac disease, an autoimmune disorder triggered by gluten, is often associated with gastrointestinal symptoms.
- However, extra-intestinal manifestations, including skin conditions, are increasingly recognized.
- The link between chronic urticaria and celiac disease, particularly in children, remains underexplored.
Observation:
- A 9-year-old girl presented with chronic urticaria.
- She was otherwise asymptomatic, with no reported gastrointestinal or typical celiac disease symptoms.
- Diagnostic workup revealed subclinical celiac disease.
Findings:
- This case demonstrates a direct association between chronic urticaria and subclinical celiac disease in a pediatric patient.
- It suggests that celiac disease can manifest solely through dermatological symptoms like chronic urticaria.
- The prevalence of chronic urticaria as a manifestation of celiac disease is currently unknown.
Implications:
- Pediatricians and gastroenterologists should consider celiac disease screening in children presenting with refractory chronic urticaria, even in the absence of gastrointestinal symptoms.
- Early diagnosis of celiac disease can prevent long-term complications.
- Further research is warranted to determine the prevalence and pathogenic mechanisms linking chronic urticaria and celiac disease.
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