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Erythrokeratoderma variabilis responding to low-dose isotretinoin
Nidhi Singh1, Devinder Mohan Thappa
1Jawaharlal Institute of Postgraduate Medical Education and Research, Department of Dermatology and Sexually Transmitted Diseases, Pondicherry, India.
Pediatric Dermatology
|March 5, 2010
Summary
A child with erythrokeratoderma variabilis experienced rapid improvement with low-dose isotretinoin. This treatment significantly cleared skin lesions within two weeks.
Area of Science:
- Dermatology
- Genetics
Background:
- Erythrokeratoderma variabilis (EKB) is a rare genetic skin disorder.
- Characterized by fluctuating erythematous, hyperkeratotic plaques and linear hyperkeratosis.
Observation:
- A 2-year-old male presented with clinical signs of erythrokeratoderma variabilis.
- The patient exhibited significant skin lesions affecting multiple body areas.
Findings:
- Treatment with low-dose isotretinoin was initiated.
- Remarkable clinical improvement was observed across all affected areas within 2 weeks.
Implications:
- Low-dose isotretinoin may be an effective therapeutic option for erythrokeratoderma variabilis.
- Early intervention can lead to rapid symptom resolution in pediatric EKB cases.
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