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Updated: Jun 15, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Systematized contact dermatitis and montelukast in an atopic boy
Mari Paz Castanedo-Tardan1, Mercedes E González, Elizabeth A Connelly
1University of Miami, Miller School of Medicine, Department of Dermatology and Cutaneous Surgery, Miami, Florida, USA.
Abstract:
Upon ingestion, the artificial sweetener, aspartame is metabolized to formaldehyde in the body and has been reportedly associated with systemic contact dermatitis in patients exquisitely sensitive to formaldehyde. We present a case of a 9-year-old Caucasian boy with a history of mild atopic dermatitis that experienced severe systematized dermatitis after being started on montelukast chewable tablets containing aspartame. Patch testing revealed multiple chemical sensitivities which included a positive reaction to formaldehyde. Notably, resolution of his systemic dermatitis only occurred with discontinuation of the montelukast chewables.
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