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Updated: Jun 15, 2026

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Acute postoperative seizures after epilepsy surgery - a long-term outcome predictor?
K Å Alfstad1, M I Lossius, G K Røste
1National Centre for Epilepsy, Rikshospitalet University Hospital, Oslo, Norway. kristin.alfstad@epilepsy.no
Acute postoperative seizures (APS) are not reliable predictors of long-term seizure recurrence after epilepsy surgery. Female gender was the only significant predictor in multivariate analysis for seizure outcomes.
Area of Science:
- Neurology
- Neurosurgery
- Epileptology
Background:
- The prognostic value of acute postoperative seizures (APS) following epilepsy surgery remains debated.
- Defining APS as seizures within the first week post-surgery is crucial for outcome prediction.
Purpose of the Study:
- To evaluate acute postoperative seizures (APS) as a predictor of long-term seizure outcomes after epilepsy surgery.
- To identify other potential predictors of seizure recurrence.
Main Methods:
- Retrospective analysis of 48 patients undergoing temporal and extra-temporal epilepsy surgery.
- Forty patients had lesional surgery with a minimum of 2-year postoperative follow-up.
Main Results:
- 53% of patients achieved seizure freedom at 2-year follow-up.
- Univariate analysis indicated APS, high pre-surgery antiepileptic drug (AED) use (≥6), pathological postoperative EEG, and female gender were associated with seizure recurrence.
Conclusions:
- APS, high pre-surgery AED burden, and pathological postoperative EEG may predict seizure recurrence.
- Only female gender remained a significant predictor in multivariate analysis for epilepsy surgery outcomes.
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