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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...

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Related Experiment Video

Updated: Jun 15, 2026

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

Genetic susceptibility in tuberculosis.

Jae-Joon Yim1, Paramasivam Selvaraj

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.

Respirology (Carlton, Vic.)
|March 5, 2010
PubMed
Summary

Host genetics significantly influence tuberculosis (TB) susceptibility. Research identifies numerous genes, like human leucocyte antigen and pattern recognition receptors, linked to TB risk across diverse populations.

Area of Science:

  • Immunogenetics
  • Tuberculosis Research
  • Human Genetics

Background:

  • Host genetic factors play a crucial role in determining individual susceptibility to tuberculosis (TB).
  • Extensive research using case-control, candidate gene, and genome-wide linkage studies has explored these genetic influences.
  • Previous studies have identified numerous candidate genes associated with differential TB susceptibility across various ethnic groups.

Purpose of the Study:

  • To review and synthesize the current understanding of host genetic factors influencing tuberculosis susceptibility.
  • To highlight key genes and genetic variations implicated in TB risk.
  • To discuss the heterogeneity in findings and potential explanations like host-pathogen and gene-environment interactions.

Main Methods:

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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

Related Experiment Videos

Last Updated: Jun 15, 2026

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish
07:00

Modeling Tuberculosis in Mycobacterium marinum Infected Adult Zebrafish

Published on: October 8, 2018

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

  • Review of existing literature on host genetics and tuberculosis.
  • Analysis of findings from case-control, candidate gene, and genome-wide linkage studies.
  • Identification and categorization of significant genetic loci and polymorphisms associated with TB.

    • Main Results:

    • Several gene families, including human leucocyte antigen (HLA) alleles, cytokines, chemokines, pattern recognition receptors (e.g., Toll-like receptors, mannose binding lectin), solute carrier family 11A member 1, and purinergic P2X7 receptor, are associated with TB susceptibility.
    • Significant heterogeneity in genetic associations has been observed across different ethnic populations.
    • Host-pathogen interactions, gene-environment interactions, and evolutionary selection pressures are proposed explanations for this heterogeneity.

    Conclusions:

    • Host genetic factors are integral to understanding tuberculosis susceptibility.
    • While genetic discoveries have not yet directly impacted TB prevention and treatment, they provide a foundation for future translational research.
    • Future research directions may involve integrating genetic findings with environmental and pathogen factors for a more comprehensive approach to TB control.