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Hemostatic abnormalities in dogs with hemangiosarcoma.

A S Hammer1, C G Couto, C Swardson

  • 1Department of Veterinary Clinical Sciences, Ohio State University, College of Veterinary Medicine, Columbus.

Journal of Veterinary Internal Medicine
|January 1, 1991
PubMed
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Hemangiosarcoma in dogs frequently causes hemostatic abnormalities, including disseminated intravascular coagulation (DIC) and thrombocytopenia, impacting survival. Early detection is crucial for managing these bleeding disorders in canine cancer patients.

Area of Science:

  • Veterinary Medicine
  • Hematology
  • Oncology

Background:

  • Hemangiosarcoma is a common and aggressive cancer in dogs.
  • Hemostatic abnormalities can complicate cancer treatment and affect prognosis.
  • Understanding the prevalence of bleeding disorders in hemangiosarcoma patients is critical.

Purpose of the Study:

  • To prospectively evaluate hemostasis profiles in dogs with hemangiosarcoma.
  • To determine the incidence of microangiopathic hemolysis and disseminated intravascular coagulation (DIC) at presentation.
  • To identify common hemostatic abnormalities associated with canine hemangiosarcoma.

Main Methods:

  • Prospective evaluation of hemostasis profiles in 24 dogs with confirmed hemangiosarcoma.
  • Defined criteria for diagnosing microangiopathic hemolysis and DIC.

Related Experiment Videos

  • Assessed platelet counts, fibrinogen degradation products, coagulation times, and red blood cell morphology.

    • Main Results:

    • Fifty percent of dogs presented with disseminated intravascular coagulation (DIC).
    • Thrombocytopenia was the most common abnormality (75% of dogs).
    • Twenty-five percent of dogs died due to hemostatic issues; only 12% had isolated microangiopathic hemolysis.

    Conclusions:

    • Hemostatic abnormalities are prevalent in dogs with hemangiosarcoma at initial diagnosis.
    • Disseminated intravascular coagulation (DIC) and thrombocytopenia are significant findings.
    • These hemostatic alterations represent an important clinical consideration in canine hemangiosarcoma management.