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Related Concept Videos

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Bioavailability: Overview01:13

Bioavailability: Overview

Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
Bioavailability: Overview01:17

Bioavailability: Overview

Bioavailability refers to the proportion of an administered drug that reaches the systemic circulation in its active, unaltered form. It is a crucial pharmacokinetic parameter that determines the effectiveness of a drug in achieving its intended therapeutic outcomes. The route of administration significantly influences bioavailability, with intravenous administration achieving 100% bioavailability as the drug directly enters the bloodstream. In contrast, oral administration often results in...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability: Influencing Factors01:22

Bioavailability: Influencing Factors

Bioavailability refers to the extent and rate at which a drug reaches systemic circulation in its active form. Extent refers to the amount of the drug that makes it into circulation, while rate is the speed at which it enters circulation. It is influenced by several factors critical for optimizing drug formulations, dosing regimens, and therapeutic outcomes.Physicochemical properties of drugs and formulationsThe solubility, stability, and dissolution rate of a drug significantly impact its...
Key Elements for Plant Nutrition02:35

Key Elements for Plant Nutrition

Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the atmosphere, the...

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Related Experiment Video

Updated: Jun 15, 2026

Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon
04:54

Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon

Published on: October 29, 2021

Micronutrient bioavailability: Dietary Reference Intakes and a future perspective.

K Michael Hambidge1

  • 1Department of Pediatrics, Section of Nutrition, University of Colorado Denver, Aurora, CO 80045, USA. michael.hambidge@ucdenver.edu

The American Journal of Clinical Nutrition
|March 5, 2010
PubMed
Summary
This summary is machine-generated.

This review examines how bioavailability was addressed for establishing Dietary Reference Intakes for key micronutrients. It highlights the need for a clear definition and consideration of homeostasis for future nutrient requirement assessments.

Related Experiment Videos

Last Updated: Jun 15, 2026

Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon
04:54

Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon

Published on: October 29, 2021

Area of Science:

  • Nutritional Science
  • Biochemistry

Background:

  • Dietary Reference Intakes (DRI) are crucial for public health.
  • Micronutrient bioavailability presents challenges in establishing DRIs.
  • Previous DRI establishment focused on specific micronutrients like folic acid, vitamin B-12, beta-carotene, iron, selenium, and zinc.

Purpose of the Study:

  • To review the approach to bioavailability in establishing DRIs.
  • To emphasize the need for a clear working definition of bioavailability.
  • To explore how factors affecting bioavailability and homeostasis influence micronutrient requirements.

Main Methods:

  • Literature review of DRI establishment processes.
  • Analysis of factors influencing micronutrient bioavailability.
  • Discussion on the role of homeostasis in nutrient requirements.

Main Results:

  • The challenge of bioavailability was addressed differently for various micronutrients.
  • A clear, working definition of bioavailability is necessary for future research.
  • Homeostasis significantly impacts nutrient requirements and should be considered separately from bioavailability.

Conclusions:

  • Future DRI establishment requires a refined understanding of bioavailability.
  • Considering homeostasis separately offers new insights into micronutrient requirements.
  • A standardized approach to bioavailability and homeostasis is recommended for nutritional science.