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Updated: Jun 15, 2026
08:50
A Nonsequencing Approach for the Rapid Detection of RNA Editing
Published on: April 21, 2022
Proteome diversification by adenosine to inosine RNA editing
Dieter Pullirsch1, Michael F Jantsch
1Department of Chromosome Biology, Max F. Perutz Laboratories, University of Vienna, Vienna, Austria. Dieter.Pullirsch@univie.ac.at
RNA Biology
|March 5, 2010
Summary
RNA editing by adenosine deaminases that act on RNA (ADARs) is widespread in mammals, altering proteins and diversifying the proteome. This review focuses on ADARs
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Nucleotide deamination alters genetic information.
- Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in RNA.
- Inosine is recognized as guanosine, affecting RNA function.
Purpose of the Study:
- Review RNA editing events impacting mRNA coding potential.
- Discuss ADARs' role in proteome diversification.
- Highlight ADARs' abundance in the nervous system.
Main Methods:
- Bioinformatic screens to identify RNA editing sites.
- Analysis of editing events in coding and non-coding mRNA regions.
- Focus on editing events altering protein sequences.
Main Results:
- RNA editing by ADARs is widespread and abundant in mammals.
- Editing sites are found in both coding and non-coding mRNA regions.
- ADAR-mediated editing diversifies the proteome, especially in the nervous system.
Conclusions:
- ADARs significantly contribute to proteome diversity through RNA editing.
- RNA editing by ADARs generates proteins distinct from their genomic sequences.
- The nervous system exhibits the highest abundance of RNA editing.
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