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Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

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Severe Kikuchi's disease responsive to immune modulation.

D Y Lin¹, M S Villegas, P L Tan

¹Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.

Singapore Medical Journal

|March 5, 2010

Summary

Kikuchi\

Area of Science:

Rheumatology and Immunology
Pathology

Background:

Kikuchi's disease is a rare, self-limiting lymphohistiocytic disorder.
Cervical lymphadenopathy is the most common presentation, lacking distinct clinical features.
Diagnosis relies on clinical suspicion and histopathological confirmation.

Observation:

A 15-year-old Chinese female presented with severe Kikuchi's disease.
The patient experienced a relapsing disease course.

Findings:

The severe, relapsing Kikuchi's disease in this patient was refractory to standard treatments.
High-dose steroid and intravenous immunoglobulin therapy proved effective in managing the condition.

Implications:

This case highlights the potential need for aggressive immunosuppressive therapy in severe Kikuchi's disease.

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Intravenous immunoglobulin may be a valuable therapeutic option for refractory cases.

Further research into Kikuchi's disease pathogenesis and treatment is warranted.