A case of effusive constrictive pericarditis caused by Streptococcus milleri
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Updated: Oct 12, 2026

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
Published on: April 7, 2015
K Hirata1, H Asato, M Maeshiro
1Division of Cardiology, Okinawa Chuba Hospital, Japan.
Abstract:
A 55-year-old male presented with hypotension and marked elevation of jugular venous pressure suggesting impaired ventricular filling. Echocardiography demonstrated a moderate amount of pericardial effusion and dense and shaggy fibrinous strands attached to the pericardia. Pericardiocentesis was performed under the diagnosis of cardiac tamponade, but normal ventricular filling could not be restored even after pericardiocentesis. Hemodynamic evaluation after pericardiocentesis revealed persisting low cardiac output, elevation and equilibration of right atrial, right ventricular end-diastolic and pulmonary capillary wedge pressures, and deep y descent. Later, surgical removal of the thickened pericardium was required. This case appeared to be typical effusive-constrictive pericarditis. Regarding etiology, a rare organism, Streptococcus milleri, proved to be responsible, while the case history and clinical situation were suggestive of a tuberculous or tumorous origin.
Insights
A rare Streptococcus milleri infection caused effusive-constrictive pericarditis, a condition mimicking tuberculosis or tumors. Surgical pericardium removal was necessary after pericardiocentesis failed to restore normal heart function.
Area of Science:
- Cardiology
- Infectious Diseases
- Pathology
Background:
- Effusive-constrictive pericarditis presents with impaired ventricular filling and hemodynamic compromise.
- Diagnosis can be challenging, often mimicking other serious conditions like tuberculosis or malignancy.
- Identifying the underlying etiology is crucial for effective treatment.
Observation:
- A 55-year-old male exhibited hypotension and elevated jugular venous pressure.
- Echocardiography revealed pericardial effusion with dense, shaggy fibrinous strands.
- Pericardiocentesis did not resolve the impaired ventricular filling or low cardiac output.
Findings:
- Hemodynamic evaluation post-pericardiocentesis showed persistent equalization of pressures and low cardiac output.
- Surgical pericardiectomy was ultimately required.
- Infectious etiology identified as Streptococcus milleri, despite initial suspicion of tuberculosis or tumor.
Implications:
- This case highlights Streptococcus milleri as a rare cause of effusive-constrictive pericarditis.
- It underscores the importance of considering infectious etiologies even with atypical presentations.
- Effective management may require both pericardiocentesis and surgical intervention.
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

