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Updated: Jun 15, 2026

Computed Tomography and Optical Imaging of Osteogenesis-angiogenesis Coupling to Assess Integration of Cranial Bone Autografts and Allografts
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Uncoupled angiogenesis and osteogenesis in nicotine-compromised bone healing

Li Ma1, Li Wu Zheng, Mai Har Sham

  • 1Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Hong Kong, Hong Kong, China.

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
|March 5, 2010
PubMed
Summary

Nicotine enhances blood vessel formation (angiogenesis) but impairs bone healing (osteogenesis) by disrupting the balance between these processes. This negatively impacts bone repair, even with increased blood supply.

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