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Updated: Jun 15, 2026

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Sterile inflammatory responses mediated by the NLRP3 inflammasome
Suzanne L Cassel1, Fayyaz S Sutterwala
1Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA. Suzanne-cassel@uiowa.edu
Abstract:
Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
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