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[Activity of doripenem against Pseudomonas spp. and Acinetobacter spp. rods]

Tomasz Bogiel1, Aleksander Deptuła, Eugenia Gospodarek

  • 1Katedra i Zakład Mikrobiologii Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy.

Medycyna Doswiadczalna I Mikrobiologia
|March 6, 2010
PubMed

Insights

Doripenem shows significant resistance in Pseudomonas and Acinetobacter species. This study compared doripenem

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Doripenem, a carbapenem antibiotic, approved in 2008 for specific infections.
  • Its activity spectrum is comparable to meropenem and imipenem/cilastatin.
  • Nonfermentative Gram-negative rods are significant pathogens in hospital-acquired infections.

Purpose of the Study:

  • To evaluate the in vitro activity of doripenem against Pseudomonas and Acinetobacter species.
  • To compare doripenem resistance rates with other carbapenems.
  • To assess cross-resistance patterns between doripenem and other carbapenems.

Main Methods:

  • In vitro susceptibility testing using the disc-diffusion method.
  • Inclusion of 235 strains: 74.9% Pseudomonas spp. and 25.1% Acinetobacter spp.
  • Bacterial identification using ID GN tests (bioMérieux).

Main Results:

  • High doripenem resistance rates observed: 28.4% in Pseudomonas spp. and 39.0% in Acinetobacter spp.
  • All susceptible/intermediate Acinetobacter spp. were also susceptible to imipenem and meropenem.
  • Significant activity of imipenem and meropenem against resistant strains, but with notable exceptions.

Conclusions:

  • Emerging resistance to doripenem in Pseudomonas and Acinetobacter necessitates careful monitoring.
  • Cross-resistance patterns vary, with some susceptible strains showing resistance to other carbapenems.
  • Further investigation into resistance mechanisms and clinical implications is warranted.

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