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Updated: Jun 15, 2026

Real-time Analysis of Gut-brain Neural Communication: Cortex wide Calcium Dynamics in Response to Intestinal Glucose Stimulation
Published on: December 29, 2023
[The important role of GLUT2 in intestinal sugar transport and absorption]
1Katedra i Zaklad Biochemii, Gdański Uniwersytet Medyczny, Gdańsk, Poland. bori@amg.gda.pl
Abstract:
The classical model of sugar absorption indicates that Na+ -glucose cotransporter, SGLT1 transports glucose from intestinal lumen to cytosol and GLUT2 transports glucose from cytosol to the blood. Recent evidence indicates that GLUT 2 is rapidly inserted into the apical membrane after a meal. Intestinal glucose absorption by the apical GLUT2 pathway can be 3 to 5-times greater then by SGLT1 et the high concentration of sugar. Apical GLUT2 insertion is regulated by pathway of calcium absorption through L-type channel Ca(v)1.3, activation of sweet taste receptors (T1R2/F1R3) and endocrine and paracrine hormones (especially insulin and GLP-2).
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