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Updated: Jun 15, 2026

03:48
Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
[Characteristics of behavioral manifestations of somatic and visceral pain during short-term immobilization stress]
Abstract:
In experiments on mice with behavior registration, we investigated the influence of short (30 min) immobilization stress on the development of somatic (the formalin test) and visceral (the acetic test) pain. It is shown that during somatic pain short immobilization prolongs the duration of the initial sharp and the remote phases of painful reaction. This is accompanied by an increase in motion activity and reduction of sleep duration. When visceral pain was evoked, such stress causes occurrence of the period of temporal hyperalgesia together with activation of mobility of animals.

