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Updated: Jun 15, 2026
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Synthesis and application of lactosylated, 99mTc chelating albumin for measurement of liver function
Philippe Chaumet-Riffaud1, Ivan Martinez-Duncker, Anne-Laure Marty
1Universite Paris-Sud 11, EA4046, Kremlin-Bicetre, F-94275, AP-HP, CHU de Bicetre, Le Kremlin-Bicetre, F-94275, Unite de Pharmacologie Chimique et Genetique, U640 INSERM, UMR8151 CNRS, Universite Paris Descartes, Paris, France. philippe.chaumet-riffaud@bct.aphp.fr
Abstract:
Neogalactosylated and neolactosylated albumins are currently used as radiopharmaceutical agents for imaging the liver asialoglycoprotein receptors, which allows the quantification of hepatic liver function in various diseases and also in healthy liver transplant donors. We developed an original process for synthesizing a chelating neolactosylated human albumin using maleimidopropyl-lactose and maleimidopropyl-diethylene triamine pentaacetic acid (DTPA) derivatives. The lactosylated protein (LACTAL) conjugate showed excellent liver uptake compared to nonlactosylated protein and a very high signal-to-noise ratio, based on functional assessment of biodistribution in mice using (99m)Tc-scintigraphy.
