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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
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ATP Driven Pumps II: P-type Pumps01:34

ATP Driven Pumps II: P-type Pumps

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Related Experiment Video

Updated: Jun 15, 2026

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
16:36

Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels

Published on: May 18, 2009

The P2X1 ion channel in platelet function.

Hu Hu1, Marc F Hoylaerts

  • 1Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.

Platelets
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

Adenosine triphosphate (ATP) released during vascular injury activates platelets via the P2X(1) receptor. This receptor is a key target for modulating platelet function and developing antithrombotic therapies.

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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
09:13

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation

Published on: April 6, 2017

Area of Science:

  • Biochemistry
  • Pharmacology
  • Hematology

Background:

  • Vascular injury releases adenosine triphosphate (ATP).
  • ATP activates platelets via the P2X(1) receptor, amplifying platelet aggregation.
  • The P2X(1) receptor plays a crucial role in platelet function and thrombosis.

Purpose of the Study:

  • To review the function of the platelet P2X(1) receptor and its downstream signaling pathways.
  • To discuss recent in vivo observations in P2X(1) gene-deficient and transgenic mice.
  • To evaluate P2X(1) as a therapeutic target for antithrombotic therapy.

Main Methods:

  • Review of findings on platelet P2X(1) receptor function and signaling over the past two decades.
  • Analysis of in vivo thrombosis models in P2X(1) gene-deficient and transgenic mice.
  • Discussion of pharmacological data regarding P2X(1) agonists and antagonists.

Main Results:

  • The P2X(1) receptor is integral to initial platelet activation and amplification.
  • Studies in P2X(1) deficient mice reveal its role in thrombosis.
  • Specific P2X(1) agonists and antagonists modulate platelet function.

Conclusions:

  • Platelet P2X(1) receptor is a validated target for managing thrombosis.
  • Inhibition of P2X(1) can modulate platelet function, offering therapeutic potential.
  • P2X(1) antagonists represent a promising strategy for antithrombotic therapy.