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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...
Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Intermolecular Forces03:13

Intermolecular Forces

Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen bonds, and dispersion...
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Updated: Jun 15, 2026

Generating Controlled, Dynamic Chemical Landscapes to Study Microbial Behavior
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Published on: January 31, 2020

Multidimensional targeting: using physical and chemical forces in unison.

R C Van Lehn1, C E Sing, H Chen

  • 1Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Current Pharmaceutical Biotechnology
|March 6, 2010
PubMed
Summary

Multidimensional targeting (MDT) combines physical, physicochemical, and biochemical factors for enhanced drug delivery. This approach considers factors across various length scales for improved therapeutic outcomes.

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Area of Science:

  • Pharmacology and Drug Delivery
  • Biophysics
  • Materials Science

Background:

  • Traditional targeted drug delivery relies heavily on specific biochemical markers.
  • Emerging research highlights the significant role of physical and physicochemical factors in targeting.
  • Integrating these factors offers a more comprehensive approach to drug delivery.

Purpose of the Study:

  • To review physicochemical factors influencing drug targeting and delivery.
  • To explore the integration of physical and physicochemical factors with biochemical markers.
  • To introduce and define the concept of multidimensional targeting (MDT).

Main Methods:

  • Literature review of physicochemical factors in drug delivery.
  • Analysis of MDT factors across different length scales.
  • Comparison of MDT with traditional biochemical targeting methods.

Main Results:

  • Physicochemical factors play a crucial role, comparable to biochemical markers, in drug targeting.
  • MDT leverages a combination of factors for potentially superior targeting efficiency.
  • The influence of MDT factors varies significantly across different scales of the delivery pathway.

Conclusions:

  • MDT represents a promising paradigm shift in targeted drug delivery.
  • Further research into MDT factors across all relevant length scales is warranted.
  • The future of targeted drug delivery likely involves a multidimensional approach.