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Related Concept Videos

Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

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Related Experiment Video

Updated: Jun 15, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

TRPC channels and their implication in neurological diseases.

Senthil Selvaraj1, Yuyang Sun, Brij B Singh

  • 1Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58201, USA.

CNS & Neurological Disorders Drug Targets
|March 6, 2010
PubMed
Summary

Transient Receptor Potential Canonical (TRPC) channels regulate cellular calcium levels, crucial for neuronal function. Dysfunction in TRPC channels is linked to neurodegenerative diseases, suggesting their therapeutic potential.

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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

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Last Updated: Jun 15, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
10:20

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Calcium ions (Ca2+) are vital intracellular messengers regulating numerous cellular functions in both excitable and non-excitable cells.
  • Cytosolic Ca2+ levels ([Ca2+](i)) are tightly controlled through mechanisms including Ca2+ release from the endoplasmic reticulum (ER) and influx across the plasma membrane (PM).
  • PM Ca2+ channels are critical for refilling ER Ca2+ stores and maintaining [Ca2+](i) for functions like neurosecretion, synaptic plasticity, and gene regulation.

Purpose of the Study:

  • To review the functional implications of Transient Receptor Potential Canonical (TRPC) channels in neuronal cells.
  • To elucidate the role of TRPC channels in neurodegeneration.
  • To explore TRPC channels as potential therapeutic targets for neurological diseases.

Main Methods:

  • Review of existing literature on TRPC channel function in neuronal cells.
  • Analysis of data linking TRPC channel alterations to neurodegenerative conditions.
  • Examination of the role of TRPC1 and TRPC3 in neuronal proliferation and neurodegeneration.

Main Results:

  • TRPC proteins are key mediators of Ca2+ entry, essential for maintaining Ca2+ homeostasis in cytosolic, ER, and mitochondrial compartments.
  • TRPC channels are implicated in various physiological processes, including neuronal proliferation, neurosecretion, and synaptic plasticity.
  • Dysregulation of TRPC channels, such as TRPC1 and TRPC3, is associated with neurodegeneration and neurological disorders like Parkinson's and Alzheimer's disease.

Conclusions:

  • TRPC channels play a significant role in normal neuronal physiology and are implicated in the pathophysiology of neurodegenerative diseases.
  • Alterations in Ca2+ homeostasis, mediated by TRPC channels, contribute to the onset and progression of neurological conditions.
  • TRPC channels represent promising therapeutic targets for the treatment of various neurological diseases.