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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Primary Healthcare Services01:30

Primary Healthcare Services

Primary care promotes wellness and prevents disease. This care includes health promotion, education, protection (such as immunizations), early disease screening, and environmental considerations. Settings providing this type of healthcare include physician offices, public health clinics, school nursing, and community health nursing.
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Related Experiment Video

Updated: Jun 15, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Evolution in pediatric health care.

Stephen J Genuis1

  • 1University of Alberta Faculty of Medicine, Edmonton, Alberta, Canada. sgenuis@ualberta.ca

Pediatrics International : Official Journal of the Japan Pediatric Society
|March 6, 2010
PubMed
Summary

Chronic diseases in children are rising, impacting families and healthcare. Integrating new research in epigenetics, molecular medicine, and environmental health into pediatric practice is crucial for better child health outcomes.

Area of Science:

  • Pediatric medicine
  • Environmental health
  • Molecular medicine
  • Epigenetics

Background:

  • Escalating rates of chronic diseases in children present a significant burden on individuals, families, and healthcare systems.
  • Modern illnesses in children are increasingly linked to nutritional and environmental factors.

Purpose of the Study:

  • To review emerging research in epigenetics, molecular medicine, and environmental health.
  • To advocate for the integration of this new knowledge into pediatric clinical practice and education.

Main Methods:

  • Comprehensive literature review of medical and scientific databases (Medline).
  • Inclusion of relevant books, conference proceedings, and government publications.

Related Experiment Videos

Last Updated: Jun 15, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
10:15

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation

Published on: March 22, 2017

Main Results:

  • Knowledge translation in medical science, particularly integrating new research into clinical practice, is progressing slowly.
  • Nutritional and environmental factors are recognized as key determinants of contemporary childhood illnesses.
  • Advanced diagnostic techniques in molecular medicine are available for disease etiology assessment.

Conclusions:

  • The current pediatric clinical paradigm needs re-evaluation based on advancements in epigenetics, molecular medicine, and environmental health.
  • Educational curricula for pediatricians should incorporate these emerging scientific fields.
  • Research findings from epigenetics, molecular medicine, and environmental health must be integrated into public health strategies and clinical practice for children.