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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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Related Experiment Video

Updated: Jun 15, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
03:19

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Nutritional developmental epigenomics: immediate and long-lasting effects.

L Attig1, A Gabory, C Junien

  • 1Biologie du Développement et Reproduction, UMR INRA-ENVA-CNRS 1198 BDR, Domaine de Vilvert, Bâtiment 231, F-78352 Jouy-en-Josas, France.

The Proceedings of the Nutrition Society
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

The epigenome, influenced by genetics and environment, shapes health throughout life. Epigenetic changes can cause disease but may be reversible through targeted interventions.

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Area of Science:

  • Genetics and Epigenetics
  • Environmental Health
  • Developmental Biology

Background:

  • Phenotype arises from complex interactions between genome, epigenome, and environment.
  • Epigenetic marks control gene expression and can be altered by environmental factors.
  • Epigenetic misprogramming during development may have lasting health consequences for offspring.

Purpose of the Study:

  • To explore the role of the epigenome as an interface between environmental exposures and the genome.
  • To investigate how environmental factors, diet, and lifestyle influence epigenetic modifications and gene expression.
  • To examine the impact of epigenetic alterations on health, aging, and disease, and their potential reversibility.

Main Methods:

  • Review of existing literature on epigenetics, gene-environment interactions, and health outcomes.
  • Analysis of how dietary factors (e.g., folate) and lifestyle exposures affect epigenetic marks.
  • Examination of sex-specific epigenetic modifications and their role in gene expression.

Main Results:

  • The epigenome is dynamically remodeled throughout life by genetic and environmental factors.
  • Environmental exposures, including diet and lifestyle, significantly impact epigenetic programming and health.
  • Epigenetic alterations accumulate with age, contributing to diseases like cancer.

Conclusions:

  • Epigenetic modifications are crucial mediators of gene-environment interactions influencing health across the lifespan.
  • Targeted epigenetic therapies and diets show promise for preventing and treating age- and lifestyle-related diseases.
  • Further research is needed to understand the complexity of epigenetic regulation and reversibility for effective interventions.