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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

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Related Experiment Video

Updated: Jun 15, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Structure-function correlations using scanning laser polarimetry in primary angle-closure glaucoma and primary

Pei-Jung Lee1, Catherine Jui-Ling Liu, Robert Wojciechowski

  • 1Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.

American Journal of Ophthalmology
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

This study found moderate correlations between retinal nerve fiber layer thickness and visual field sensitivity in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG). POAG showed stronger correlations across more retinal sectors than PACG.

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Last Updated: Jun 15, 2026

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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
07:44

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography

Published on: July 24, 2020

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Retinal Imaging

Background:

  • Glaucoma diagnosis relies on correlating structural damage (retinal nerve fiber layer thickness) with functional deficits (visual field sensitivity).
  • Scanning laser polarimetry (SLP) is a key technology for measuring RNFL thickness.
  • Understanding structure-function relationships in different glaucoma types is crucial for accurate diagnosis and management.

Purpose of the Study:

  • To evaluate the correlation between RNFL thickness measured by SLP and VF sensitivity in patients with primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG).
  • To compare the strength and significance of these correlations between POAG and PACG eyes.

Main Methods:

  • A prospective, comparative, observational case series involving 50 POAG patients and 56 PACG patients.
  • Utilized scanning laser polarimetry with variable corneal compensation (GDx VCC) and Humphrey VF analyzer.
  • Correlations were analyzed globally and by RNFL sectors using Spearman rank correlation and multivariate median regression.

Main Results:

  • Moderate structure-function correlations were observed in both POAG and PACG groups.
  • The correlation was stronger in the POAG group (r(s) = 0.51) compared to the PACG group (r(s) = 0.38).
  • Significant correlations were found in more RNFL sectors for POAG eyes than for PACG eyes.

Conclusions:

  • Both POAG and PACG exhibit moderate structure-function correlations detectable by SLP.
  • The structure-function relationship is more consistently significant across RNFL sectors in POAG compared to PACG.
  • These findings highlight potential differences in how glaucoma affects different retinal layers in POAG versus PACG.