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Related Experiment Video

Updated: Jun 15, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Bundle branch block patterns and long-term outcomes in heart failure.

Husam M Abdel-Qadir¹, Jack V Tu, Peter C Austin

¹Department of Medicine, University of Toronto, Toronto, Canada.

International Journal of Cardiology

|March 6, 2010

Summary

Left bundle branch block (LBBB) in heart failure patients indicates higher risk for death and hospitalization. Right bundle branch block (RBBB) does not independently predict worse outcomes in these patients.

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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Published on: August 30, 2024

Area of Science:

Cardiology
Clinical Medicine
Electrophysiology

Background:

The prognostic implications of left bundle branch block (LBBB) and right bundle branch block (RBBB) in hospitalized heart failure (HF) patients remain incompletely understood.
Bundle branch blocks (BBB) are common findings in patients with acute heart failure.

Purpose of the Study:

To investigate the prognostic value of LBBB and RBBB in patients hospitalized with heart failure.
To determine the association of BBB type with mortality and hospitalizations over a five-year follow-up period.

Main Methods:

Analysis of data from the EFFECT study, including 9082 hospitalized patients meeting Framingham criteria for acute heart failure.
Multinomial logistic regression and multiple Cox regression analyses were employed to assess associations between BBB type and outcomes, adjusting for relevant covariates.

Main Results:

LBBB was associated with increased risk of heart failure hospitalization (adjusted hazard ratio [HR] 1.32) and cardiovascular hospitalization (HR 1.13).
LBBB also predicted increased mortality (adjusted HR 1.10) in hospitalized heart failure patients.
Right bundle branch block (RBBB) did not show a significant independent association with increased risk of death or hospitalization.

Conclusions:

Heart failure patients with LBBB exhibit greater clinical severity and a higher risk of adverse outcomes, including death and hospitalizations.
In contrast, RBBB in heart failure patients does not independently predict worse prognosis.
These findings highlight the importance of differentiating BBB types for risk stratification in heart failure management.