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Related Experiment Video

Updated: Jun 15, 2026

Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

Comment on "Movement intention after parietal cortex stimulation in humans".

Hans-Otto Karnath1, Svenja Borchers, Marc Himmelbach

  • 1Section of Neuropsychology, Center of Neurology, Hertie-Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany. Karnath@uni-tuebingen.de

Science (New York, N.Y.)
|March 6, 2010
PubMed
Summary

Direct electrical stimulation (DES) may deactivate, not activate, the human cortex during movement intention studies. This uncertainty about DES effects hinders its use in validating cognitive models.

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Area of Science:

  • Neuroscience
  • Cognitive Science

Background:

  • Direct electrical stimulation (DES) is used to probe the human cortex and understand movement intention.
  • Previous interpretations of DES effects assumed cortical activation.

Discussion:

  • This study questions the assumption of cortical activation by DES.
  • It is proposed that DES might actually induce cortical deactivation.
  • This ambiguity challenges the established understanding of DES mechanisms.

Key Insights:

  • The precise effect of DES on cortical activity remains uncertain.
  • The interpretation of DES experiments relies on understanding its true impact (activation vs. deactivation).

Outlook:

  • Further research is needed to clarify the neurophysiological effects of DES.
  • Resolving the activation/deactivation question is crucial for validating cognitive models of movement intention.