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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

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Related Experiment Video

Updated: Jun 15, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Epigenetics and cancer.

Rajnee Kanwal1, Sanjay Gupta

  • 1Dept. of Urology, Case Western Reserve Univ., Univ. Hospitals Case Medical Center, 10900 Euclid Ave., Cleveland, OH 44106, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications, including DNA methylation and histone changes, play a crucial role in cancer development. Understanding these epigenetic abnormalities offers new avenues for cancer diagnosis, treatment, and prevention.

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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
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An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Related Experiment Videos

Last Updated: Jun 15, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Cancer is increasingly recognized as involving both genetic and epigenetic alterations.
  • Epigenetic abnormalities precede the onset of many cancers.
  • Traditional views focused primarily on genetic mutations.

Purpose of the Study:

  • To highlight the central role of epigenetic modifications in human diseases, particularly cancer.
  • To discuss the genomic reprogramming observed in cancer cells.
  • To explore the potential of epigenetic targets for cancer prevention and treatment.

Main Methods:

  • Review of current research on epigenetic mechanisms in cancer.
  • Documentation of genomic reprogramming in cancer cells, including DNA methylation, histone modification, and RNA-dependent regulation.
  • Analysis of the link between genetic and epigenetic factors in carcinogenesis.

Main Results:

  • Extensive genomic reprogramming, involving DNA methylation, histone modification, and RNA regulation, is documented in cancer cells.
  • Epigenetic alterations are key events preceding cancer development.
  • Understanding epigenetic mechanisms improves cancer diagnosis and outcome prediction.

Conclusions:

  • Carcinogenesis involves both genetic and epigenetic alterations, leading to a better understanding of cancer development.
  • Reversible epigenetic mechanisms offer novel targets for cancer prevention and treatment strategies.
  • Epigenetics is a rapidly expanding field with significant implications for oncology.