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Updated: Jun 15, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Versatile chiroptics of peptide-induced assemblies of metalloporphyrins
Hirokuni Jintoku1, Takashi Sagawa, Tsuyoshi Sawada
1Department of Applied Chemistry & Biochemistry, Kumamoto University, 2-39-1 Kurokami, Kumamoto, 860-8555, Japan.
Abstract:
Zinc porphyrin functionalized with double long-chain alkylated L-glutamide (GTPP-Zn) was synthesized for the first time, and its self-assembling behaviour was investigated in nonpolar organic solvents. The uniqueness of this functionalized porphyrin is characterized by its drastic colour change from dark green to purple via the formation of chirally stacked structures through selective axial coordination on zinc with pyridine derivatives. In this paper, we report the versatility of the GTPP-Zn assembly process as a stimuli-responsive chiroptical switching system and describe the remarkable ligand-specific induction of secondary chirality accompanied by aggregation morphological change.
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