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Updated: Jun 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Diffuse interstitial lung disease: overlaps and uncertainties.

Simon L F Walsh¹, David M Hansell

¹Department of Radiology, Royal Brompton Hospital, London, UK.

European Radiology

|March 6, 2010

Summary

This summary is machine-generated.

Diagnosing interstitial lung disease (ILD) faces challenges from pathologist variation and sampling errors. An integrated approach combining clinical, imaging, and histopathology is recommended, acknowledging overlapping disease patterns.

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Last Updated: Jun 15, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

Pulmonology
Pathology
Radiology

Background:

Histopathological analysis of lung biopsies is crucial for diagnosing idiopathic interstitial pneumonias.
Interobserver variation and sampling issues can compromise the reliability of histopathological diagnoses.
The 2002 American Thoracic Society and European Respiratory Society guidelines advocate an integrated approach for interstitial lung disease (ILD) diagnosis.

Purpose of the Study:

To review current classification methods for interstitial lung disease (ILD).
To discuss the applicability of various ILD classification systems.
To address the challenges posed by overlapping disease patterns in ILD diagnosis.

Main Methods:

Review of existing literature on ILD classification.
Analysis of the 2002 American Thoracic Society and European Respiratory Society recommendations.
Discussion of histopathological interobserver variation and sampling error in ILD diagnosis.

Main Results:

The traditional 'gold standard' of histopathology has been replaced by a 'silver standard' integrating clinical, radiological, and histopathological data.
Rigid classification systems struggle to accommodate overlapping ILD patterns.
A pigeonhole approach may overlook hybrid ILD entities.

Conclusions:

Integrated diagnostic approaches are essential for accurate ILD diagnosis.
Overlapping disease patterns and diagnostic limitations necessitate flexible classification strategies.
Further research is needed to refine ILD classification and address diagnostic ambiguities.