Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
Repressible Operon: trp Operon01:21

Repressible Operon: trp Operon

The trp operon in Escherichia coli exemplifies a repressible operon. It regulates the synthesis of tryptophan through repressor-mediated transcriptional control and attenuation. This dual regulatory mechanism ensures tryptophan biosynthesis occurs only when needed, conserving cellular resources.Structure of the trp OperonThe trp operon consists of five structural genes (trpE, trpD, trpC, trpB, and trpA) that encode enzymes for tryptophan biosynthesis. These genes are transcribed as a single...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory organs,...
Cotranslational Protein Translocation01:20

Cotranslational Protein Translocation

Translocation of proteins across membranes is an ancient process that occurs even in bacteria and archaebacteria. In fact, the components of the translocation machinery are still conserved between prokaryotes and eukaryotes.
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity-regulated circSamm50 modulates mitochondrial dynamics and spine structural plasticity.

Cell reports·2026
Same author

Loss of miRNA-153 promotes EndMT and compromises lung vascular integrity.

American journal of respiratory cell and molecular biology·2026
Same author

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.

Nature communications·2026
Same author

Pulmonary Vascular Signaling in Pulmonary Hypertension: Potential Role of Endothelial Ca<sup>2+</sup> Signaling in Cellular Senescence and Inflammasome Activation.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension.

Nature medicine·2026
Same author

Loss of miRNA-153 promotes endothelial-to-mesenchymal transition and compromises lung vascular integrity.

bioRxiv : the preprint server for biology·2025
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

Introduction to TRP channels: structure, function, and regulation.

Michael Y Song1, Jason X-J Yuan

  • 1University of California, San Diego, CA, USA.

Advances in Experimental Medicine and Biology
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

Transient receptor potential (TRP) channels are diverse ion channels crucial for sensory perception and cellular signaling. Dysregulation of TRP channels is linked to various human diseases, highlighting their physiological importance.

More Related Videos

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jun 15, 2026

Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Area of Science:

  • Physiology
  • Molecular Biology
  • Biophysics

Background:

  • Transient receptor potential (TRP) channels are a diverse superfamily of ion channels.
  • They play critical roles in integrating signals and mediating various physiological processes.
  • TRP channels exhibit varied ion selectivity and gating mechanisms.

Purpose of the Study:

  • To summarize the diverse functions and physiological importance of TRP ion channels.
  • To highlight the role of TRP channels in sensory perception and cellular signaling.
  • To underscore the implication of TRP channel dysfunction in human diseases.

Main Methods:

  • Review of existing literature on TRP channel structure, function, and physiology.
  • Analysis of TRP channel involvement in sensory modalities (vision, taste, olfaction, etc.).
  • Examination of TRP channel roles in cellular events and disease pathogenesis.

Main Results:

  • TRP channels mediate ion flux (Na+, Ca2+), influencing cell membrane potential and excitability.
  • They are essential for sensory functions including touch, temperature, and pain sensation.
  • Mutations and altered TRP channel activity are associated with diseases like pulmonary hypertension.

Conclusions:

  • TRP channels are vital signal integrators in human physiology.
  • Their diverse functions underscore their importance in health and disease.
  • Further research into TRP channels may reveal therapeutic targets for various conditions.