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Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

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Related Experiment Video

Updated: Jun 15, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Infections in the immunocompromised.

Andrew Cant1, Theresa Cole

  • 1Paediatric Immunology & Infectious Diseases, Newcastle General Hospital, NE4 6BE, Newcastle upon Tyne, UK. Andrew.Cant@nuth.nhs.uk

Advances in Experimental Medicine and Biology
|March 6, 2010
PubMed
Summary
This summary is machine-generated.

Infections in immunocompromised children are more severe and life-threatening than in immunocompetent children. These infections are often caused by rare organisms and are increasingly common worldwide.

Related Experiment Videos

Last Updated: Jun 15, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
07:42

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

Area of Science:

  • Pediatric Infectious Diseases
  • Immunology

Background:

  • Infections in immunocompromised individuals present unique challenges compared to immunocompetent individuals.
  • These infections can be more severe, life-threatening, and diagnostically complex.
  • The incidence of immunocompromised children is increasing globally.

Purpose of the Study:

  • To highlight the distinct characteristics of infections in immunocompromised children.
  • To underscore the growing global concern regarding these infections.

Main Methods:

  • This study is a review and synthesis of existing literature on infections in immunocompromised children.
  • Analysis of epidemiological trends and clinical presentations.

Main Results:

  • Infections in immunocompromised children are demonstrably more serious and carry a higher risk of mortality.
  • Diagnosis is often complicated by atypical pathogens and delayed recognition.
  • A growing number of children worldwide are becoming immunocompromised due to various underlying conditions.

Conclusions:

  • The unique and severe nature of infections in immunocompromised children necessitates specialized attention and management strategies.
  • The increasing global prevalence warrants further research and public health initiatives.