Related Experiment Video

Updated: Jun 15, 2026

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

Contemporary immunotherapy of solid tumors: from tumor-associated antigens to combination treatments

Giulio C Spagnoli1, Marzieh Ebrahimi, Giandomenica Iezzi

  • 1Department of Biomedicine, University of Basel, Institute of Surgical Research and Hospital Management (ICFS), Basel, Switzerland. gspagnoli@uhbs.ch

Current Opinion in Drug Discovery & Development
|March 6, 2010
PubMed

Insights

Cancer immunotherapies show promise but require reassessment. New treatments are emerging to improve T-cell responses against solid tumors, offering hope for better clinical outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Cancer immunotherapy harnesses the patient's immune system to combat tumors.
  • Tumor-associated antigens on cancer cells can be targeted by T-cells.
  • Current immunotherapies face limitations in achieving clinical goals.

Purpose of the Study:

  • To review recent advancements in cancer immunotherapy for solid tumors.
  • To discuss the reassessment of immunotherapy procedures based on clinical and experimental data.
  • To highlight the development of next-generation antitumor treatments.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of clinical trial data on immunotherapy efficacy.
  • Examination of experimental data on immune response mechanisms.

Main Results:

  • Specific immune responses alone may not be sufficient for tumor control.
  • Complexity of immune response mechanisms necessitates a reevaluation of current strategies.
  • Development of novel reagents and second-generation immunotherapies is ongoing.

Conclusions:

  • A comprehensive reassessment of cancer immunotherapy is crucial.
  • Next-generation treatments incorporating new reagents show potential for pharmaceutical relevance.
  • Further research is needed to optimize immunotherapy for solid tumors.

More Related Videos

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...