Related Experiment Video
Updated: Jun 15, 2026

Measuring Constipation in a Drosophila Model of Parkinson's Disease
Published on: September 22, 2023
[Non-motor disorders in Parkinson's disease: introduction and general features]
L Argandoña-Palacios1, A B Perona-Moratalla, F Hernández-Fernández
1Hospital General Universitario de Albacete, España. luci_ap@hotmail.com
Introduction:
Two hundred years ago James Parkinson accurately described the disease that bears his name today, focusing not only on motor aspects but also on non-motor symptoms suffered by these patients.
Development:
Non-motor symptoms are prevalent and decrease the quality of life of the patients with Parkinson's disease. In recent years, some non-motor scales have been developed to avoid the problem of underdiagnosis. Moreover, some of them have been proposed as clinical predictors for Parkinson's disease and it is has been suggested that individuals with any of these non-motor symptoms and without motor manifestations of the disease could be the aim for neuroprotective therapies when they become available.
Conclusions:
Non-motor symptoms are prevalent and have a great impact in the quality of life of patients. Therefore, it is important to detect and treat them. Their role as predictors of the disease is unclear yet.
Related Concept Videos
Parkinson Disease l: Introduction
Parkinson's Disease: Overview
Parkinson Disease ll: Pathophysiology
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Alterations in Muscle Tone lll
Alterations in Muscle Tone ll