Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Graves' Disease I: Introduction

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

Graves Disease II: Pathophysiology

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

Pathophysiology of Vomiting

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through interaction...

Bulimia Nervosa

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional divergence of duplicated genes results in a novel blast resistance gene Pi50 at the Pi2/9 locus.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2015

Same author

Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes.

Scientific reports·2015

Same author

Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis.

BioMed research international·2015

Same author

Alternative NF-κB Isoforms in the Drosophila Neuromuscular Junction and Brain.

PloS one·2015

Same author

Grape seed proanthocyanidin protects liver against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress.

World journal of gastroenterology·2015

Same author

Serum Levels of Progranulin Are Closely Associated with Microvascular Complication in Type 2 Diabetes.

Disease markers·2015

Search research articles

Related Experiment Video

Updated: Jun 15, 2026

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Published on: August 4, 2023

Case Report: Recurrent severe vomiting due to hyperthyroidism.

Li-ying Chen¹, Bo Zhou, Zhou-wen Chen

¹Department of Family Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China.

Journal of Zhejiang University. Science. B

|March 6, 2010

Summary

Severe vomiting is an uncommon symptom of thyrotoxicosis. This case highlights hyperthyroidism as a potential cause of unexplained vomiting, even when peptic ulcers are present.

Related Experiment Videos

Last Updated: Jun 15, 2026

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Ear Plaster Therapy as a Safe and Effective Treatment for Gestational Vomiting

Published on: August 4, 2023

Area of Science:

Endocrinology
Gastroenterology

Background:

Thyrotoxicosis, a condition of excess thyroid hormones, typically presents with symptoms like weight loss, rapid heart rate, and heat intolerance.
Severe vomiting is an atypical and rare manifestation of thyrotoxicosis.

Observation:

A 24-year-old male presented with a seven-year history of recurrent severe vomiting and significant weight loss (15 kg).
Initial investigations revealed chronic gastritis and a peptic ulcer, with symptoms unresponsive to standard gastrointestinal treatments.
Presenting symptoms and laboratory data confirmed hyperthyroidism.

Findings:

Treatment with propylthiouracil, an anti-thyroid medication, led to complete resolution of the patient's severe vomiting within one month.
This case underscores that unexplained vomiting can be a presenting symptom of hyperthyroidism.

Implications:

Clinicians should consider hyperthyroidism in the differential diagnosis of patients with unexplained severe vomiting, even in the presence of gastrointestinal findings like peptic ulcers.
Recognizing atypical presentations of hyperthyroidism is crucial for timely and accurate diagnosis, preventing prolonged diagnostic delays and inappropriate treatments.