Related Experiment Video
Updated: Jun 15, 2026
A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
Acquired reactive perforating collagenosis: a clinicopathologic study of 15 cases from Saudi Arabia
M B Satti1, A H Aref, A A Raddadi
1Departments of Pathology, King Abdulaziz Medical City, Jeddah, Saudi Arabia. sattimb@ngha.med.sa
Background:
Perforating dermatoses include a family of disease characterized by transepidermal elimination of collagen. Despite being described many years ago in association with systemic disease, it is still clinically misdiagnosed.
Objective:
A retrospective clinical and pathologic review that will increase clinical and pathologic diagnostic awareness of this entity and explore associated systemic disease.
Patients And Methods:
In this report, we present from Saudi Arabia for the first time details of a series of patients seen at the King Abdulaziz Medical City, WR, Jeddah, Saudi Arabia, during the period 2002-2009.
Results:
The study revealed 15 histologically confirmed cases of acquired reactive perforating collagenosis (ARPC). Patients were predominantly adult females with a mean age of 54 years. The lesions were pruritic, predominantly multiple, erythematous excoriated papules and umblicated nodules centrally crusted with an average duration of 6 months, involving the extremities with or without the trunk in 12 patients. Associated systemic disease included diabetes mellitus in 12 patients and chronic renal failure on dialysis in 8 patients. The provisional clinical differential diagnosis included perforating collagenosis in only eight patients.
Conclusion:
ARPC is not uncommon in Saudi Arabia. The noduloulcerative lesions involve predominantly the extremities, and diabetes mellitus is the most common associate. It is hoped that this article will increase awareness for recognition of this entity to start appropriate therapy.
Insights
Acquired reactive perforating collagenosis (ARPC) is a commonly misdiagnosed condition. This study highlights its prevalence in Saudi Arabia, often linked to diabetes mellitus and chronic renal failure.
Area of Science:
- Dermatology
- Pathology
Background:
- Perforating dermatoses are characterized by transepidermal collagen elimination.
- These conditions are often misdiagnosed despite associations with systemic diseases.
Purpose of the Study:
- To increase clinical and pathologic diagnostic awareness of acquired reactive perforating collagenosis (ARPC).
- To explore systemic diseases associated with ARPC.
Main Methods:
- A retrospective clinical and pathologic review of patients seen at King Abdulaziz Medical City, Jeddah, Saudi Arabia (2002-2009).
Main Results:
- Fifteen cases of ARPC were histologically confirmed, predominantly in adult females (mean age 54).
- Lesions were typically pruritic, erythematous, excoriated papules/nodules on extremities, present for ~6 months.
- Commonly associated systemic diseases included diabetes mellitus (12 patients) and chronic renal failure requiring dialysis (8 patients).
Conclusions:
- ARPC is not uncommon in Saudi Arabia, with noduloulcerative lesions predominantly on extremities.
- Diabetes mellitus is the most frequent associated systemic condition.
- Increased awareness is crucial for timely recognition and appropriate therapy.
More Related Videos
04:42Picrosirius Red Staining for Semiquantitative Histopathologic Evaluation of Collagen Deposition in Murine Models of Chronic Lung Allograft Rejection
Published on: March 21, 2025
07:29Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015