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Updated: Jun 15, 2026

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Published on: September 17, 2015
Pharmacodynamics of a losartan transdermal system for the treatment of hypertension
M Shahbaz Shams1, M Intakhab Alam, Asgar Ali
1Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Aims:
Transdermal therapeutic systems were developed using the polymers, Eudragit E 100 and polyvinyl pyrrolidone VA 64 in a film casting assembly. The medicated films were evaluated for physical properties, in vitro drug release studies, in vitro skin permeation studies, and pharmacodynamic studies.
Results:
The physical parameters were found to be very satisfactory with high drug content (>99%). The in vitro drug release studies were performed using paddle-over-disc assembly specified in USP XXIII. The pharmacodynamic studies were carried out using tail cuff method in Wistar albino rats. Hypertension was induced by methyl prednisolone acetate subcutaneously for 2 weeks. The developed matrix patch was found to decrease the blood pressure (25.42% reduction in mean systolic blood pressure of rats) significantly (P < 0.001) in proximity of the normal value and it was maintained for 24 hours.
Conclusion:
It can be concluded that the developed transdermal matrix patch holds promise for the management of hypertension that needs to be validated by clinical trials.
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