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Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with

Phuong Ha-Lien Tran1, Thao Truong-Dinh Tran, Kyoung-Ho Lee

  • 1Kangwon National University, College of Pharmacy, Bioavailability Control Laboratory, Chuncheon, Republic of Korea.

Expert Opinion on Drug Delivery
|March 9, 2010
PubMed
Summary

pH-modified solid dispersions enhance drug dissolution for poorly soluble, pH-dependent drugs. Mechanistic studies reveal how pH modifiers improve drug release and solubilization in these systems.

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