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Modified-Release Drug Delivery Systems: Rate-Programmed II

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Modified-Release Drug Delivery Systems: Classification

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-Release Drug Delivery Systems: Influencing Factors

Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...

Modified-Release Drug Delivery Systems: Overview

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Modified-Release Drug Delivery Systems: Drug Release Characteristics

Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...

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Related Experiment Video

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Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

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Published on: October 20, 2020

Polymeric materials and formulation technologies for modified-release tablet development.

J Zarate¹, M Igartua, R M Hernández

¹Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, 01006 - Vitoria-Gasteiz, Spain. jon.zarate@ehu.es

Mini Reviews in Medicinal Chemistry

|March 9, 2010

Summary

Modified-release drug delivery systems have advanced significantly. This review covers technologies for modified-release tablets and polymers controlling drug release.

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Last Updated: Jun 15, 2026

Production of Near-Infrared Sensitive, Core-Shell Vaccine Delivery Platform

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Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Polymer Science

Background:

Significant progress in drug delivery has been achieved through modified-release (MR) dosage forms.
MR dosage forms offer improved therapeutic outcomes by controlling the rate and extent of drug release.

Purpose of the Study:

To review technologies for designing modified-release (MR) drug delivery tablets.
To explore the application of synthetic and natural polymers in controlling drug release from MR dosage forms.

Main Methods:

Literature review of recent advancements in modified-release drug delivery technologies.
Analysis of polymer-based strategies for modulating drug release kinetics.
Categorization of MR tablet design technologies.

Main Results:

Detailed overview of various technologies employed in the fabrication of MR tablets.
Discussion on the role of different synthetic and natural polymers in achieving sustained or targeted drug release.
Identification of key factors influencing drug release profiles from MR systems.

Conclusions:

The development of MR dosage forms relies on sophisticated design technologies and carefully selected polymers.
Continued innovation in polymer science and formulation technology is crucial for advancing modified-release drug delivery.