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Updated: Jun 15, 2026
09:45
Measuring Cardiac Autonomic Nervous System (ANS) Activity in Children
Published on: April 29, 2013
A new method to analyse the pace of child development: Cox regression validated by a bootstrap resampling procedure
Christian Denne1, Sarah Maag, Nicole Heussen
1Department of Pediatrics, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. denne.christian@gmx.net
BMC Pediatrics
|March 9, 2010
Summary
Perinatal factors like birth weight and gestational age impact neuromotor development. A Cox regression model identified these factors, but retrospective data may introduce bias due to memory changes over time.
Area of Science:
- Neonatal development and neuromotor acquisition.
- Statistical modeling in clinical research.
Background:
- Cross-sectional studies identify perinatal factors affecting neuromotor development.
- The precise factors influencing the age of acquiring distinct abilities remain unclear.
Purpose of the Study:
- To investigate perinatal factors influencing the age of acquiring distinct neuromotor abilities.
- To evaluate the utility of the Cox regression model in identifying these factors.
Main Methods:
- Retrospective analysis of 796 neonates from Aachen University Hospital (2000/2001).
- Outcome data from 466 children via structured interviews, alongside perinatal data.
- Bootstrap selection and multivariate Cox regression identified influencing factors.
- Five age cohorts of 163 normally developed children assessed parental recall bias.
Main Results:
- Birth weight, gestational age, congenital cardiac disease, and periventricular leukomalacia were significant predictors (p < 0.05).
- Parental assessment of bladder control ability was influenced by the time elapsed since birth in control cohorts.
Conclusions:
- The combined bootstrap and Cox regression approach effectively identifies perinatal factors for neuromotor skill acquisition.
- Findings align with previous cross-sectional studies.
- Retrospective data collection poses a bias risk due to memory alteration over time, suggesting prospective trials.
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