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Mortality among patients with tuberculosis requiring intensive care: a retrospective cohort study

Denise R Silva¹, Diego M Menegotto, Luis F Schulz

¹Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, RS, Brazil. denise.rossato@terra.com.br

BMC Infectious Diseases

|March 9, 2010

Abstract

Background:

To describe the characteristics of patients with tuberculosis (TB) requiring intensive care and to identify the factors that predicts in-hospital mortality in a city of a developing country with intermediate-to-high TB endemicity.

Methods:

We conducted a retrospective, cohort study, between November 2005 and November 2007. The patients with TB requiring intensive care were included. Predictors of mortality were assessed. The primary outcome was the in-hospital mortality.

Results:

During the study period, 67 patients with TB required intensive care. Of them, 62 (92.5%) had acute respiratory failure and required mechanical ventilation. Forty-four (65.7%) patients died. Coinfection with human immunodeficiency virus was present in 46 (68.7%) patients. Early intensive care unit admission and ventilator-associated pneumonia were independently associated with the in-hospital mortality.

Conclusions:

In this study we found a high mortality rate in TB patients requiring intensive care, especially in those with an early ICU admission.

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