Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Endoscopic Procedures I: Esophagogastroduodenoscopy01:29

Endoscopic Procedures I: Esophagogastroduodenoscopy

An Esophagogastroduodenoscopy (EGD) is a diagnostic procedure in which an endoscopist uses a flexible, lighted endoscope to visualize the upper gastrointestinal (GI) tract. The procedure includes visualizing the oropharynx, esophagus, stomach, and the first part of the small intestine, the duodenum.
During an EGD, the endoscope can be used to:
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
The Unfolded Protein Response01:37

The Unfolded Protein Response

The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
E2 Reaction: Kinetics and Mechanism02:45

E2 Reaction: Kinetics and Mechanism

SN2 substitutions and E2 eliminations of alkyl halides proceed via a concerted pathway. While the nucleophile attacks the alpha carbon in SN2 reactions, it functions as a strong base and abstracts a beta hydrogen in the E2 mechanism. The rate-limiting transition state in E2 elimination reactions is characterized by partially broken carbon–hydrogen and carbon–halogen bonds and a partially formed pi bond between the alpha and beta carbons. The beta hydrogen and halide are eliminated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

German guidelines for the diagnosis and treatment of squamous-cell carcinoma and adenocarcinoma of the esophagus-version 4.0.

ESMO gastrointestinal oncology·2026
Same author

Zeitschrift fur Gastroenterologie·2022
Same author

Zeitschrift fur Gastroenterologie·2021
Same author

[Drug-induced gastrointestinal bleeding].

Der Internist·2019
Same author

[Treatment with platelet aggregation inhibitors and additive proton pump inhibitors?]

Der Internist·2018
Same author

[S2k-guideline Helicobacter pylori and gastroduodenal ulcer disease].

Zeitschrift fur Gastroenterologie·2016

Related Experiment Video

Updated: Jun 15, 2026

Using the Endoscope for Endobronchial Ultrasound in the Esophagus
04:35

Using the Endoscope for Endobronchial Ultrasound in the Esophagus

Published on: November 21, 2023

Staging role of EUS.

W Fischbach1, O Al-Taie

  • 1Medizinische Klinik II und Klinik für Palliativmedizin, Klinikum Aschaffenburg, Akademisches Lehrkrankenhaus der Universität Würzburg, Germany. med2-aschaffenburg@t-oniline.de

Best Practice & Research. Clinical Gastroenterology
|March 9, 2010
PubMed
Summary

Endoscopic ultrasound (EUS) is valuable for staging gastric lymphoma, assessing wall infiltration and lymph node involvement. While useful for initial staging and predicting Helicobacter pylori response, its role in guiding treatment decisions and follow-up requires further investigation.

Related Experiment Videos

Last Updated: Jun 15, 2026

Using the Endoscope for Endobronchial Ultrasound in the Esophagus
04:35

Using the Endoscope for Endobronchial Ultrasound in the Esophagus

Published on: November 21, 2023

Area of Science:

  • Gastroenterology
  • Oncology
  • Medical Imaging

Background:

  • Gastric lymphoma diagnosis and staging are crucial for prognosis and treatment.
  • Accurate assessment of locoregional disease extent is essential for effective management.
  • Endoscopic ultrasound (EUS) is a key imaging modality in gastrointestinal diagnostics.

Purpose of the Study:

  • To evaluate the utility of endoscopic ultrasound (EUS) in the staging of gastric lymphoma.
  • To determine the prognostic value of EUS in predicting treatment response.
  • To assess the role of EUS in guiding therapeutic decisions for gastric lymphoma.

Main Methods:

  • Review of current literature and clinical guidelines regarding EUS in gastric lymphoma.
  • Analysis of EUS capabilities in assessing gastric wall infiltration and lymph node involvement.
  • Evaluation of EUS for predicting treatment response to Helicobacter pylori eradication, chemotherapy, and radiation therapy.

Main Results:

  • EUS is highly useful for locoregional staging of gastric lymphoma, assessing gastric wall infiltration and perigastric lymph node involvement.
  • EUS should be integrated into the standard staging procedures for gastric lymphoma.
  • EUS has prognostic value for treatment response to Helicobacter pylori eradication but limited value in predicting response to chemotherapy or radiation.
  • The benefit of advanced EUS techniques like miniechoendoscopes, elastography, and guided biopsies is not yet proven for gastric lymphoma.

Conclusions:

  • EUS is a valuable tool for initial staging of gastric lymphoma and should be part of standard procedures.
  • EUS aids in predicting treatment response to H. pylori eradication, offering prognostic insights.
  • EUS has limited utility in routine follow-up investigations for predicting response to radiation or chemotherapy.