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Updated: Jun 15, 2026

Non-invasive Imaging of the Innate Immune Response in a Zebrafish Larval Model of Streptococcus iniae Infection

Non-invasive Imaging of the Innate Immune Response in a Zebrafish Larval Model of Streptococcus iniae Infection

Published on: April 21, 2015

Transcriptome profiling of zebrafish infected with Streptococcus suis.

Zongfu Wu¹, Wei Zhang, Yan Lu

¹Key Lab Animal Disease Diagnostic and Immunology, Ministry of Agriculture, Nanjing Agricultural University, Weigang 1, Nanjing 210095, Jiangsu, China.

Microbial Pathogenesis

|March 9, 2010

Summary

Zebrafish gene expression reveals immune responses to Streptococcus suis infection. This study identifies key upregulated immune genes and downregulated metabolic pathways, aiding understanding of S. suis pathogenesis.

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Area of Science:

Microbiology
Immunology
Zebrafish Model Organisms

Background:

Streptococcus suis is a significant swine pathogen and an emerging zoonotic agent.
Zebrafish have been previously validated as a model for S. suis virulence studies.

Purpose of the Study:

To identify gene expression alterations in zebrafish upon infection with S. suis serotype 2.
To elucidate the molecular mechanisms underlying zebrafish response to S. suis.

Main Methods:

Utilized Affymetrix Zebrafish GeneChip for microarray analysis.
Analyzed differentially expressed genes using Gene Ontology and KEGG pathway analysis.
Validated microarray data with quantitative real-time PCR.

Main Results:

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189 differentially expressed genes identified: 125 upregulated and 64 downregulated.
Upregulated genes are associated with immune and inflammatory responses, including complement activation and defense.
Downregulated genes are linked to metabolic processes like glycolysis and amino acid metabolism.

Conclusions:

Zebrafish model effectively reveals host responses to S. suis infection.
Identified specific immune-related genes provide insights into S. suis pathogenesis.
Findings support the use of zebrafish for further research into S. suis virulence mechanisms.