Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities
Guo-Liang Zhang1, Changshui Chen, Yulan Xiong
1State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road #38, Beijing, China.
Carbohydrate Research
|March 9, 2010
Abstract:
Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents.
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