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Recanalization and its correlation to outcome after cerebral venous thrombosis

Jukka Putaala1, Sini Hiltunen, Oili Salonen

  • 1Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. jukka.putaala@hus.fi

Journal of the Neurological Sciences
|March 9, 2010
PubMed

Insights

Recanalization after cerebral vein thrombosis (CVT) occurred in most patients, with nearly half achieving complete vessel reopening. However, recanalization status did not predict patient outcomes in multivariate analysis, though headache was more frequent with no recanalization.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Radiology

Background:

  • Limited research exists on recanalization rates and outcomes in cerebral vein thrombosis (CVT).
  • Assessing vessel recanalization is crucial for understanding CVT patient prognosis.

Purpose of the Study:

  • To investigate recanalization rates in patients with CVT.
  • To determine the impact of recanalization on clinical outcomes in CVT patients.

Main Methods:

  • Retrospective cohort study of 91 patients with non-invasively verified CVT.
  • Follow-up imaging at 4 months or autopsy to assess vessel status (complete, partial, no recanalization).
  • Modified Rankin Scale used to define complete recovery (score of 0).

Main Results:

  • Complete recanalization was observed in 47% of patients, partial in 34%, and none in 19%.
  • Older age (>37 years), male sex, and absence of identified risk factors were associated with partial or no recanalization.
  • Increasing age and chronic symptom onset predicted poor outcomes, independent of recanalization status.
  • Headache was more prevalent in patients with no recanalization (44%).

Conclusions:

  • Approximately half of CVT patients achieve complete recanalization.
  • Recanalization status was not a significant predictor of outcome in multivariate analysis.
  • No recanalization was associated with a higher incidence of residual headaches.
Abstract

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